Coen A C Ottenheijm Selected Research

Muscular Diseases (Myopathy)

8/2021	Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics.
1/2021	NEM6, KBTBD13-Related Congenital Myopathy: Myopathological Analysis in 18 Dutch Patients Reveals Ring Rods Fibers, Cores, Nuclear Clumps, and Granulo-Filamentous Protein Material.
1/2021	Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.
1/2020	Nebulin: big protein with big responsibilities.
1/2016	Mutation-specific effects on thin filament length in thin filament myopathy.
11/2014	Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
6/2013	Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.
6/2013	Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.
5/2011	Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.

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Coen A C Ottenheijm Research Topics

Disease

16	Muscle Weakness 01/2021 - 07/2009
15	Nemaline Myopathies (Nemaline Myopathy) 01/2021 - 07/2009
9	Muscular Diseases (Myopathy) 08/2021 - 05/2011
7	Atrophy 01/2022 - 02/2011
5	Critical Illness (Critically Ill) 10/2021 - 04/2014
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2008 - 07/2005
2	Body Weight (Weight, Body) 01/2022 - 01/2019
2	Disease Progression 01/2020 - 04/2014
2	Neoplasms (Cancer) 05/2015 - 12/2011
2	Heart Failure 06/2008 - 07/2007
1	Cardiomegaly (Heart Hypertrophy) 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Lung Injury 01/2022
1	Glucose Intolerance 01/2022
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 01/2021
1	Hypertrophy 01/2020
1	Fibrosis (Cirrhosis) 01/2016
1	Facioscapulohumeral Muscular Dystrophy 10/2013
1	Neuromuscular Diseases (Neuromuscular Disease) 06/2013
1	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 04/2012
1	Hypoxia (Hypoxemia) 01/2006
1	Hyperoxia 01/2006

Drug/Important Bio-Agent (IBA)

13	nebulinIBA 01/2020 - 07/2009
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2005
6	Contractile ProteinsIBA 01/2018 - 01/2006
5	ConnectinIBA 01/2020 - 03/2006
5	UbiquitinIBA 05/2015 - 07/2005
4	TroponinIBA 08/2021 - 06/2013
4	Myosins (Myosin)IBA 11/2015 - 11/2006
4	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2015 - 11/2006
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022
1	CytokinesIBA 01/2022
1	CK-2017357IBA 01/2021
1	Nonsense Codon (Nonsense Mutation)IBA 01/2020
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2019
1	CollagenIBA 01/2016
1	CalciumIBA 06/2013
1	tenascin XIBA 04/2012
1	Glycoproteins (Glycoprotein)IBA 04/2012
1	TropomyosinIBA 05/2011
1	Proteasome InhibitorsIBA 06/2007
1	Messenger RNA (mRNA)IBA 11/2006
1	Ligases (Synthetase)IBA 11/2006
1	Caspase 3 (Caspase-3)IBA 11/2006
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2006
1	Reactive Nitrogen SpeciesIBA 01/2006
1	3-nitrotyrosineIBA 01/2006
1	Arginine (L-Arginine)FDA Link 01/2006
1	omega-N-Methylarginine (NG Monomethyl L Arginine)IBA 01/2006
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 07/2005

Therapy/Procedure

5	Mechanical Ventilators (Ventilator) 10/2021 - 05/2015
5	Therapeutics 01/2021 - 05/2011
4	Artificial Respiration (Mechanical Ventilation) 01/2022 - 05/2015
3	Length of Stay 01/2018 - 05/2015
1	Ventilator Weaning 10/2021
1	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 01/2018
1	Thoracotomy 12/2011